Abstract :

ABSTRACT

Objective: This study aims to explore the significance of serum asymmetric dimethylarginine (ADMA) and nitric oxide (NO) levels in the pathogenesis and severity of hemolysis, elevated liver enzymes, and low platelets syndrome (HELLP syndrome), Eclampsia, and Pre-eclampsia.

Methods: Ninety patients, comprising those with HELLP syndrome (n=30), Eclampsia (n=30), Pre-eclampsia (n=30), and 30 healthy pregnant women for comparison, were included. Pregnancy duration was determined by last menstrual period and ultrasonographic fetal biometric measurements, with inclusion criteria set at 32 weeks and above. Serum ADMA, Arginine, and NO levels were assessed for all groups.

Results: No significant differences were observed in age, gravida, parity, gestational week, hemoglobin, fibrinogen, international normalized ratio, and Arginine levels among the groups (p>0.05). In the HELLP syndrome, Eclampsia, and late-onset Pre-eclampsia groups, systolic and diastolic blood pressure, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and ADMA levels were significantly elevated (p<0.001). Conversely, platelet and nitric oxide levels were diminished compared to the control group (p<0.001).

Conclusions: Serum ADMA and NO levels may serve as predictive markers for complications such as Eclampsia, Pre-eclampsia, and HELLP syndrome, aiding in personalized treatment approaches for affected patients.

Keywords: Pre-eclampsia (PE), Eclampsia, HELLP syndrome, ADMA, NO, Arginine.