Tuna Akcal¹, Hanım Guler Sahin², Kazım Uckan^3*

¹Department of Gynecology and Obstetrics, Training and Research Hospital, Turkey

²Department of Gynecology and Obstetrics School of Medicine, Yuzuncu Yil University, Van, Turkey

³Department of Gynecology and Obstetrics, Training and Research Hospital, Van, Turkey

Correspondence to: Kazım Uckan, Department of Gynecology and Obstetrics, Training and Research Hospital, Turkey. E-mail: kazım_uckan@gmail.com

Received: February 09, 2023; Accepted: February 25, 2023; Published: March 05, 2023

Citation: Akcal T, Sahin HG, Uckan K. The Pathophysiological Role of Serum Asymmetric Dimethylarginine (ADMA) and Nitric Oxide (NO) in Patients with Preeclampsia and HELLP Syndrome. J Stem Cells Dev. 2023;1(1):1-8.

Copyright: © 2023 Uckan K. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

ABSTRACT

Objective: This study aims to explore the significance of serum asymmetric dimethylarginine (ADMA) and nitric oxide (NO) levels in the pathogenesis and severity of hemolysis, elevated liver enzymes, and low platelets syndrome (HELLP syndrome), Eclampsia, and Pre-eclampsia.

Methods: Ninety patients, comprising those with HELLP syndrome (n=30), Eclampsia (n=30), Pre-eclampsia (n=30), and 30 healthy pregnant women for comparison, were included. Pregnancy duration was determined by last menstrual period and ultrasonographic fetal biometric measurements, with inclusion criteria set at 32 weeks and above. Serum ADMA, Arginine, and NO levels were assessed for all groups.

Results: No significant differences were observed in age, gravida, parity, gestational week, hemoglobin, fibrinogen, international normalized ratio, and Arginine levels among the groups (p>0.05). In the HELLP syndrome, Eclampsia, and late-onset Pre-eclampsia groups, systolic and diastolic blood pressure, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and ADMA levels were significantly elevated (p<0.001). Conversely, platelet and nitric oxide levels were diminished compared to the control group (p<0.001).

Conclusions: Serum ADMA and NO levels may serve as predictive markers for complications such as Eclampsia, Pre-eclampsia, and HELLP syndrome, aiding in personalized treatment approaches for affected patients.

Keywords: Pre-eclampsia (PE), Eclampsia, HELLP syndrome, ADMA, NO, Arginine.